Accession Number : ADA325575

Title :   The Use of Combinatorial Heavy and Light Chain Libraries and Site Specific Mutagenesis to Create Antibody Biosensors for Metal Ions.

Descriptive Note : Final rept. 1 Apr 92-31 Mar 94,

Corporate Author : PENNSYLVANIA STATE UNIV UNIVERSITY PARK DEPT OF CHEMISTRY

Personal Author(s) : Benkovic, Stephen J.

PDF Url : ADA325575

Report Date : 21 APR 1997

Pagination or Media Count : 4

Abstract : We investigated the potential catalytic activity qf the Zn(II) containing antibody against a variety of ester. and phosphomonoester and diester substrates. They were designed on the basis of their structural resemblance to the 43C9 hapten. None of the materials proved to be substrates for the Zn(II) containing antibody and the project was terminated.

Descriptors :   *IONS, *ZINC, *ANTIBODIES, *HEAVY METALS, METALS, DETECTORS, SUBSTRATES, MUTATIONS, CATALYSTS, BIOLOGICAL DETECTION.

Subject Categories : Medicine and Medical Research
      Metallurgy and Metallography

Distribution Statement : APPROVED FOR PUBLIC RELEASE