Accession Number : ADA325697

Title :   Mechanisms Associated with the Toxicity of Polyhalogenated Cyclic Hydrocarbons and Heavy Metals.

Descriptive Note : Final rept. 1 Nov 93-31 Oct 96,

Corporate Author : CREIGHTON UNIV HEALTH SCIENCES CENTER OMAHA NE

Personal Author(s) : Stobs, Sidney J.

PDF Url : ADA325697

Report Date : OCT 1996

Pagination or Media Count : 13

Abstract : We have hypothesize that the toxic manifestations of polyhalogenated cyclic hydrocarbons and heavy metals are at least in part induced through a series of events involving the production of reactive oxygen species, activation of the protein kinase C system and release of tumor necrosis factor-a (TNFa). The sequence of these events is not known, and the relationship between these events and the induction of stress protein has not been studied. Both in vivo and in vitro effects on these parameters as well as acute and chronic studies will be determined. The above hypothesis will be tested by completing the following specific aims. Excellent progress has been made relative to the specific objectives of this research project. Based on the results which have been completed during the past three years, 21 manuscripts were published or are in press in refereed journals, and 14 presentations have been made at national and international scholarly meetings.

Descriptors :   *TOXICITY, *IN VITRO ANALYSIS, *IN VIVO ANALYSIS, *HALOGENATED HYDROCARBONS, *CYCLIC COMPOUNDS, STRESSES, ACTIVATION, PRODUCTION, POLYMERS, PROTEINS, REACTIVITIES, OXYGEN, HYPOTHESES, INDUCTION SYSTEMS, HEAVY METALS.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE