Accession Number : ADA325785

Title :   Splicing Variants of Estrogen Receptor in Breast Cancer.

Descriptive Note : Annual rept. 30 Sep 95-26 Sep 96,

Corporate Author : STATE UNIV OF NEW YORK AT STONY BROOK

Personal Author(s) : Miksicek, Richard J.

PDF Url : ADA325785

Report Date : OCT 1996

Pagination or Media Count : 17

Abstract : Work continued on a systematic analysis of the abundance of estrogen receptor mRNA splicing variants in several human breast tumor specimens. Plasmid vectors have been developed to allow the expression of these variant receptor proteins and to enable characterization of their function. Results have been obtained with respect to stability of expression, DNA-binding activity, subcellular localization, and transcriptional activity of each of six exon-skipped receptor variants.

Descriptors :   *ESTROGENS, *BREAST CANCER, HUMANS, PROTEINS, DEOXYRIBONUCLEIC ACIDS, PLASMIDS, VARIATIONS, RIBONUCLEIC ACIDS, GENETICS, RECEPTOR SITES(PHYSIOLOGY), SPLICES, MAMMARY GLANDS, DISEASE VECTORS, STEROIDS.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE