Accession Number : ADA325788

Title :   Acute Oral Toxicity Evaluation and Genotoxicity Testing of Hexakis (2,2,2-Trifluornethoxy) Cyclotriphosphazene, A Replacement Candidate for Ozone Depleting Substances.

Descriptive Note : Final rept. Sep-Nov 96,

Corporate Author : MANTECH ENVIRONMENTAL TECHNOLOGY INC DAYTON OH

Personal Author(s) : Wolfe, Robin E. ; Ellis, David H. ; Leahy, Harry F. ; Vinegar, Allen ; Sharma, S.

PDF Url : ADA325788

Report Date : MAY 1997

Pagination or Media Count : 27

Abstract : The DoD requires the development of toxicity profiles for chemical substitute candidates, that have little or no ozone depleting potential, to replace ozone depleting substances such as chloro- and fluorocarbons and halons. Hexakis (2,2,2-trifluoroethoxy) cyclotriphosphazene (Hexakis) was identified as a possible replacement candidate for ozone- depleting fire extinguishants. An acute oral toxicity assessment utilizing male and female Fischer 344 rats and genotoxicity testing utilizing the Ames assay were performed on Hexakis. No deaths or signs of toxic stress were observed in any of the rats orally dosed at the limit test value of 5g Hexakis/hg body weight. Body weights during the subsequent 14-day observation period appeared unaffected by treatment. In the Ames assay, Hexakis did not produce mutagenicity in the bacterial (Salmonella) system. In summary, Hexakis did not produce toxicity via the oral route of administration and was determined not to be genotoxic.

Descriptors :   *TOXICITY, *SALMONELLA, *ORAL DOSAGE, *ORAL INTAKE, *FLUORINATED HYDROCARBONS, TEST AND EVALUATION, STRESSES, RATS, HUMANS, CHEMICALS, SIGNS AND SYMPTOMS, CHROMOSOMES, PROFILES, REPLACEMENT, SUBSTITUTES, FIRE EXTINGUISHING AGENTS, OZONE, BODY WEIGHT.

Subject Categories : Biochemistry
      Medicine and Medical Research
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE