Accession Number : ADA325794

Title :   Acute Inhalation Toxicity Evaluation of a 9:1 Mixture of 1,1,1,3,3,3-Hexafluoropropane and 1-Bromopropane: A Replacement Candidate for Ozone Depleting Substances.

Descriptive Note : Final rept. Nov-Dec 96,

Corporate Author : MANTECH ENVIRONMENTAL TECHNOLOGY INC DAYTON OH

Personal Author(s) : Wolfe, Robin E. ; Ellis, David H. ; Leahy, Harry F. ; Vinegar, Allen

PDF Url : ADA325794

Report Date : MAY 1997

Pagination or Media Count : 24

Abstract : The DOD requires the development of a toxicity profile for chemical substitute candidates, that have little or no ozone depleting potential, to replace ozone depleting substances such as chloro-and bromofluorocarbons (halons). A 9:1 mixture of 1,1,1,3,3,3-hexafluoropropane (HFC-236fa) and 1-bromopropane (BP) was identified as a possible replacement candidate for ozone-depleting fire extinguishants. An acute inhalation toxicity assessment utilizing male and female Fischer 344 rats was performed on this mixture. No deaths occurred in any of the rats exposed to 5.09 mg/L of the 9:1 HFC-236fa and BP mixture. Body weights of male rats during the subsequent 14-day observation period appeared unaffected by treatment. Female rat mean body weights averaged <3 g from their initial body weights at the end of the postexposure period, but no signs of toxic stress were observed in any animals. The 9:1 mixture of HFC-236fa and BP did not produce acute toxicity via the inhalation route.

Descriptors :   *DEPLETION, *TOXICITY, *OZONE, *INHALATION, TEST AND EVALUATION, STRESSES, CHEMICALS, SIGNS AND SYMPTOMS, PROFILES, REPLACEMENT, ANIMALS, SUBSTITUTES, BODY WEIGHT.

Subject Categories : Toxicology
      Inorganic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE