Accession Number : ADA325796
Title : Triplex Forming Therapeutic Agents for Breast Cancer.
Descriptive Note : Final rept.,
Corporate Author : ALABAMA UNIV UNIVERSITY
Personal Author(s) : Miller, Donald M.
PDF Url : ADA325796
Report Date : DEC 1995
Pagination or Media Count : 71
Abstract : The overall goal of this proposal was to develop sequence specific DNA binding compounds which are targeted to the promoters of the c-myc, c-Ha-ras, and neu genes. Inhibition of expression of these genes, which appear to play an important role in the development of the malignant phenotype of breast carcinoma cells would be expected to inhibit cellular proliferation and possibly induce apoptosis.
Descriptors : *DEOXYRIBONUCLEIC ACIDS, *GENES, *BREAST CANCER, EPITHELIUM, NEOPLASMS, THERAPY, CARCINOGENS, INHIBITION, CELLS(BIOLOGY), MAMMARY GLANDS, NUCLEOTIDES.
Subject Categories : Biochemistry
Genetic Engineering and Molecular Biology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE