Accession Number : ADA325810

Title :   Regulation of the Estrogen Structural Gene in Breast Tissue by the AH Receptor.

Descriptive Note : Final rept. 1 Aug 94-31 Jul 96,

Corporate Author : ROCHESTER UNIV NY

Personal Author(s) : Gasiewicz, Thomas A.

PDF Url : ADA325810

Report Date : AUG 1996

Pagination or Media Count : 44

Abstract : The objectives of this research are three-fold: (1) to determine the cell- and developmentally related expression and activation of the AhR in rat mammary tissue, (2) to examine the ability of AhR agonists to affect the expression of the ER in mammary tissue; and (3) to examine the mechanism by which the AhR down regulates the expression of the ER structural gene.

Descriptors :   *GENES, *ESTROGENS, *BREAST CANCER, ACTIVATION, TISSUES(BIOLOGY), RATS, DEOXYRIBONUCLEIC ACIDS, RECEPTOR SITES(PHYSIOLOGY), CHLORINATED HYDROCARBONS, MAMMARY GLANDS.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE