Accession Number : ADA325824

Title :   Epidermal Growth Factor-Like Ligands in Breast Cancer.

Descriptive Note : Annual rept. 22 Aug 95-21 Aug 96,

Corporate Author : LA JOLLA CANCER RESEARCH FOUNDATION CA

Personal Author(s) : Adamson, Eileen D.

PDF Url : ADA325824

Report Date : SEP 1996

Pagination or Media Count : 86

Abstract : Cripto-1 (Cr-1) and Amphiregulin (Ar) are two EGF-like growth factors that occur at higher levels in breast cancer cells and tissues. We have shown that they occur in the late stages of mammary cell proliferation in virgin, pregnant and lactating mouse mammary glands. in order to test the roles of Cr-1, we infected CID9 normal mouse mammary cells with retroviruses over-expressing Cr-1, or with retroviruses that express an antisense version, in order to inhibit the production of this Polypepide.

Descriptors :   *LIGANDS, *EPIDERMIS, *GROWTH(PHYSIOLOGY), *BREAST CANCER, TISSUES(BIOLOGY), STIMULATION(PHYSIOLOGY), NEOPLASMS, GENES, MICE, INHIBITION, EMBRYOS, PREGNANCY, CELLS(BIOLOGY), RECEPTOR SITES(PHYSIOLOGY), MAMMARY GLANDS, CYTOCHEMISTRY, IMMUNOCHEMISTRY, RETROVIRUSES.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE