Accession Number : ADA325834

Title :   Cell-Cell Adhesion and Breast Cancer.

Descriptive Note : Annual rept. 15 Dec 95-14 Dec 96,

Corporate Author : GEORGETOWN UNIV WASHINGTON DC

Personal Author(s) : Byers, Stephen W.

PDF Url : ADA325834

Report Date : JAN 1997

Pagination or Media Count : 57

Abstract : The objective of this proposal is to elucidate the role of cell-cell adhesion and calcium dependent cell adhesion molecules cadherins in breast tumor progression. We will test the hypothesis that in addition to the occasional loss of E-cadherin expression, breast tumor progression is more realistically modeled by a loss of strong cell-cell adhesion resulting from defects in any one or more of the steps (molecules) required for E-cadherin function. During the past year we have used biophysical techniques to measure cell-cell adhesive strength Serine phosphorylation of Beta 3-catenin was found to regulate protein stability in a pathway involving the tumor suppressor gene APC.

Descriptors :   *ADHESION, *CELLS(BIOLOGY), *BREAST CANCER, STABILITY, HUMANS, MOLECULES, PROTEINS, NEOPLASMS, GENES, AMINO ACIDS, MAMMARY GLANDS, BETA PARTICLES, SERINE, PHOSPHORYLATION, METASTASIS.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE