Accession Number : ADA325862

Title :   Comparison of Anatomical Characteristics of the Skin for Several Laboratory Animals.

Descriptive Note : Interim rept. Nov 93-Oct 94,

Corporate Author : GEO-CENTERS INC NEWTON CENTRE MA

Personal Author(s) : Grabau, John H. ; Dong, Lily ; Mattie, David R. ; Jepson, Gary W. ; McDougal, James N.

PDF Url : ADA325862

Report Date : DEC 1995

Pagination or Media Count : 35

Abstract : Anatomical differences between experimental species may affect the relative rates of chemical penetration into and through the skin. Computer-based morphometric techniques were used to quantitate selected morphologic characteristics within the epidermal and dermal regions of dorsal midline skin of the Hartley and IAF (Hairless) Guinea pigs, B56C3F1 and SKHl (Hairless) mice, Fuzzy and Fischer (F-344) rats, mixed breed farm pigs and Rhesus monkeys. The cutaneous thickness measurements included the stratum comeum, the stratum germinativum, the underlying viable epidermis and the dermis. Vascular measurements included the average depth and fractional area for capillaries, venules and arterioles. Adnexal measurements included the average depth and fractional area of hair follicles and sebaceous glands and the average number of follicular ostia per unit surface area. Statistical analysis revealed comparative differences that could not be attributable to animal size. These measurements will allow for an improved understanding of the anatomical differences of skin in laboratory animals. This understanding is critical to facilitate extrapolation of chemical absorption in animals to humans.

Descriptors :   *CHEMICALS, *PENETRATION, *COMPUTER APPLICATIONS, *ANATOMICAL MODELS, *LABORATORY ANIMALS, *SKIN DISEASES, MEASUREMENT, THICKNESS, SIZES(DIMENSIONS), RATS, HUMANS, MORPHOLOGY, RATES, SURFACES, VIABILITY, ANIMALS, STATISTICAL ANALYSIS, ABSORPTION, ANATOMY, MICE, CARDIOVASCULAR SYSTEM, EPIDERMIS, RHESUS MONKEYS, EXTRAPOLATION, SWINE, GUINEA PIGS, CAPILLARIES(ANATOMY).

Subject Categories : Biochemistry
      Anatomy and Physiology
      Computer Programming and Software

Distribution Statement : APPROVED FOR PUBLIC RELEASE