Accession Number : ADA325990
Title : TGFa-myc Interactions in Mammary Tumorigenesis.
Descriptive Note : Annual rept. 1 Sep 95-31 Aug 96,
Corporate Author : GEORGETOWN UNIV WASHINGTON DC
Personal Author(s) : Dickson, Robert B.
PDF Url : ADA325990
Report Date : SEP 1996
Pagination or Media Count : 35
Abstract : The goals our project were twofold. First, we were to characterize rapid onset bitransgenic TGF alpha-Myc mouse mammary tumors for expression of sex steroid receptors and for indicators of epithelial differentiation status. Second, we were to characterize tumors for amplification of genes encoding TGF alpha, c-Myc, EGF receptor, the Myc protein partner Myn, and for expression or relevant cyclins.
Descriptors : *INTERACTIONS, *MAMMARY GLANDS, *GROWTH(PHYSIOLOGY), *BREAST CANCER, EPITHELIUM, HUMANS, BIOCHEMISTRY, PROTEINS, NEOPLASMS, CODING, MOLECULAR BIOLOGY, GENES, AMPLIFICATION, TRANSPLANTATION, STEROIDS, ALPHA PARTICLE REACTIONS, ESTROGENS, SEX HORMONES.
Subject Categories : Biochemistry
Genetic Engineering and Molecular Biology
Anatomy and Physiology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE