Accession Number : ADA325990

Title :   TGFa-myc Interactions in Mammary Tumorigenesis.

Descriptive Note : Annual rept. 1 Sep 95-31 Aug 96,

Corporate Author : GEORGETOWN UNIV WASHINGTON DC

Personal Author(s) : Dickson, Robert B.

PDF Url : ADA325990

Report Date : SEP 1996

Pagination or Media Count : 35

Abstract : The goals our project were twofold. First, we were to characterize rapid onset bitransgenic TGF alpha-Myc mouse mammary tumors for expression of sex steroid receptors and for indicators of epithelial differentiation status. Second, we were to characterize tumors for amplification of genes encoding TGF alpha, c-Myc, EGF receptor, the Myc protein partner Myn, and for expression or relevant cyclins.

Descriptors :   *INTERACTIONS, *MAMMARY GLANDS, *GROWTH(PHYSIOLOGY), *BREAST CANCER, EPITHELIUM, HUMANS, BIOCHEMISTRY, PROTEINS, NEOPLASMS, CODING, MOLECULAR BIOLOGY, GENES, AMPLIFICATION, TRANSPLANTATION, STEROIDS, ALPHA PARTICLE REACTIONS, ESTROGENS, SEX HORMONES.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE