Accession Number : ADA326012
Title : Role of Matrix Metalloproteinases and Their Tissue Inhibitors in Human Breast Adenocarcinoma.
Descriptive Note : Annual rept. 1 Sep 95-31 Aug 96,
Corporate Author : MIAMI UNIV FL
Personal Author(s) : Gunja-Smith, Zeenat
PDF Url : ADA326012
Report Date : SEP 1996
Pagination or Media Count : 54
Abstract : The overall objective of this research is to explore the role of matrix metalloproteinases (MMPs) and the tissue inhibitors of metal- loproteinases (TIMPs) in the invasive and metastatic processes of human breast tumors. The hypothesis to be tested is that an imbalance arises through normal or elevated production of MMPs accompanied by a diminished production of inhibitory TIMPs. Metastasis of an initially localized tumor to vital organs is the dominant cause of cancer related deaths.
Descriptors : *TISSUES(BIOLOGY), *ENZYMES, *BREAST CANCER, EPITHELIUM, HUMANS, PROTEINS, NEOPLASMS, INHIBITORS, MAMMARY GLANDS, METASTASIS.
Subject Categories : Biochemistry
Anatomy and Physiology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE