Accession Number : ADA326063

Title :   Homeobox Genes in Normal, Preneoplastic, and Neoplastic Mammary Glands.

Descriptive Note : Annual rept. 1 Jan 96-31 Dec 96,

Corporate Author : CALIFORNIA UNIV SANTA CRUZ

Personal Author(s) : Daniel, Charles W.

PDF Url : ADA326063

Report Date : JAN 1997

Pagination or Media Count : 33

Abstract : In 1996, the highlight of our research is undoubtedly the discovery of a new, large family of homeotic genes in the human breast. These genes were cloned, partially characterized, and their expression has been studied. They are activated in lumenal breast epithelial cells. We feel that the discovery of the IRX family of homeogenes will open the door to a wealth of interesting studies in the mammary gland and in embryogenesis. Our approach is to use the mouse mammary tumor model system for those observations and experiments that describe the patterns of expression of these genes.

Descriptors :   *GENES, *MAMMARY GLANDS, *BREAST CANCER, EPITHELIUM, HORMONES, HUMANS, NEOPLASMS, DEOXYRIBONUCLEIC ACIDS, CLONES, CELLS(BIOLOGY), RIBONUCLEIC ACIDS, LESIONS.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE