Accession Number : ADA326065

Title :   Line-i Retrotransposons as Mutagens in Human Breast Cancer.

Descriptive Note : Annual rept.,

Corporate Author : ARMED FORCES INST OF PATHOLOGY WASHINGTON DC

Personal Author(s) : Fanning, Thomas G.

PDF Url : ADA326065

Report Date : OCT 1996

Pagination or Media Count : 9

Abstract : Our long range goals focus on the isolation of cellular genes that are affected by LlHs transposition. These genes are presumably the ones whose inactivation (by insertional mutagenesis), or activation (by readthrough transcription), is one of the steps in the pathway leading to malignancy. Specifically we have proposed to: (1) Place a 'tagged', transpositionally competent LlHs element into non-malignant human breast epithelial cells. (2) Identify malignant cells arising from the non-malignant cell population and isolate and characterize sequences into which the tagged LlHs element has transposed.

Descriptors :   *MUTAGENS, *BREAST CANCER, ACTIVATION, EPITHELIUM, HUMANS, PROTEINS, ISOLATION, NEOPLASMS, MUTATIONS, CODING, GENES, CELLS(BIOLOGY), RIBONUCLEIC ACIDS.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE