Accession Number : ADA326076

Title :   Molecular Detection of Breast Cancer.

Descriptive Note : Annual rept. 9 Jan 96-8 Jan 97,

Corporate Author : MICHIGAN UNIV ANN ARBOR

Personal Author(s) : Clarke, Michael F.

PDF Url : ADA326076

Report Date : FEB 1997

Pagination or Media Count : 26

Abstract : This project is designed to develop novel approaches to detect breast cancer cells that contaminate peripheral blood and bone marrow, and to remove such contaminating cells. An RT-PCR assay has been developed to detect breast cancer cells, and a novel gene therapy vector has been developed to kill contaminating cancer cells. Blood and bone marrow samples obtained from patients with breast cancer are being collected. These samples will be analyzed to determine whether the Kl9 RT-PCR assay can be used to predict outcome. Next, a gene therapy vector, the bcl-xs adenovirus, has been developed.

Descriptors :   *MOLECULES, *BIOLOGICAL DETECTION, *BREAST CANCER, SAMPLING, THERAPY, MOLECULAR BIOLOGY, GENES, CONTAMINATION, CELLS(BIOLOGY), ASSAYING, BONE MARROW, BLOOD, ADENOVIRUSES.

Subject Categories : Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE