Accession Number : ADA327079

Title :   Regulation of Breast Cancer Invasion and Metastasis by Progestin and Antiprogestin.

Descriptive Note : Final rept. 26 Sep 94-25 Sep 96,

Corporate Author : LONG ISLAND JEWISH-HILLSIDE MEDICAL CENTER NEW HYDE PARK NY

Personal Author(s) : Shi, Yuenian E.

PDF Url : ADA327079

Report Date : OCT 1996

Pagination or Media Count : 66

Abstract : It is known that breast cancer is dependent upon estrogenic hormones in about one-third of all clinical cases and can be inhibited by antiestrogenic antagonists. We are now hypothesizing that progestational hormones may also function as a stimulus for onset and progression of breast cancer and antiprogestin can interrupt these processes. Antiestrogen tomaxifen treatment enhances the progestational stimulation of tumor growth. Mammary derived growth inhibitor (MDGI) is a mammary epithelial cell growth inhibitor and differentiation factor.

Descriptors :   *PROGESTERONE, *METASTASIS, *BREAST CANCER, HORMONES, STIMULATION(PHYSIOLOGY), CLINICAL MEDICINE, NEOPLASMS, GENES, MAMMARY GLANDS, GROWTH(PHYSIOLOGY), ESTROGENS.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE