Accession Number : ADA327087
Title : Cell-Matrix Interactions in Breast Carcinoma Invasion.
Descriptive Note : Annual rept. 15 Dec 95-14 Dec 96,
Corporate Author : NEW YORK UNIV MEDICAL CENTER NY
Personal Author(s) : Giancotti, Filippo G.
PDF Url : ADA327087
Report Date : MAR 1997
Pagination or Media Count : 12
Abstract : Transgenic mice carrying an activated form of the N-ras oncogene under the control of the Mammary Tumor Virus Long Terminal Repeat promoter developed mammary carcinomas with a high frequency during the first few months of their life. The alpha 6 beta 4 and, to a minor extent, the alpha 2 beta 1 integrin were found to be upregulated and diffusely distributed at the tumor cell surface in the primary lesions of these mice.
Descriptors : *INTERACTIONS, *CELLS(BIOLOGY), *BREAST CANCER, EPITHELIUM, TISSUES(BIOLOGY), ADHESION, NEOPLASMS, GENES, MICE, CARCINOGENS, VIRUSES, IN VIVO ANALYSIS, MAMMARY GLANDS.
Subject Categories : Biochemistry
Genetic Engineering and Molecular Biology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE