Accession Number : ADA327087

Title :   Cell-Matrix Interactions in Breast Carcinoma Invasion.

Descriptive Note : Annual rept. 15 Dec 95-14 Dec 96,

Corporate Author : NEW YORK UNIV MEDICAL CENTER NY

Personal Author(s) : Giancotti, Filippo G.

PDF Url : ADA327087

Report Date : MAR 1997

Pagination or Media Count : 12

Abstract : Transgenic mice carrying an activated form of the N-ras oncogene under the control of the Mammary Tumor Virus Long Terminal Repeat promoter developed mammary carcinomas with a high frequency during the first few months of their life. The alpha 6 beta 4 and, to a minor extent, the alpha 2 beta 1 integrin were found to be upregulated and diffusely distributed at the tumor cell surface in the primary lesions of these mice.

Descriptors :   *INTERACTIONS, *CELLS(BIOLOGY), *BREAST CANCER, EPITHELIUM, TISSUES(BIOLOGY), ADHESION, NEOPLASMS, GENES, MICE, CARCINOGENS, VIRUSES, IN VIVO ANALYSIS, MAMMARY GLANDS.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE