Accession Number : ADA327128

Title :   Transforming Growth Factor-beta Receptors in Human Breast Cancer.

Descriptive Note : Annual rept. 1 May 96-30 Apr 97,

Corporate Author : YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE

Personal Author(s) : Reiss, Michael

PDF Url : ADA327128

Report Date : MAY 1997

Pagination or Media Count : 10

Abstract : This project addresses three fundamental research issues. The first question is whether or not molecular lesions of the genes involved in the TGFB signaling pathway contribute to the origin and/or progression of breast cancer. We expect changes in these genes to be relatively late events, perhaps characteristic of metastatic cancer. Secondly, we propose to determine how molecular lesions in the TGFB receptor and/or Smad genes affect receptor function, and how they might play a role in the development and/or progression of breast cancer. Thirdly, we intend to examine the question whether genetic lesions in TGFB receptor and/or Smad genes are able to predict the outcome of patients with breast cancer. Because the anti-tumor effects of anti-estrogens such as tamoxifen are thought to be mediated by the auto-and paracrine induction of TGFB, we wish to test the hypothesis that resistance of hormone-receptor positive cancers to tamoxifen is the result of inactivation of TGFB pathway genes.

Descriptors :   *GROWTH(PHYSIOLOGY), *BREAST CANCER, HORMONES, HUMANS, MOLECULES, PROTEINS, MUTATIONS, CODING, GENES, INHIBITORS, RECEPTOR SITES(PHYSIOLOGY), LESIONS, BETA PARTICLES, ESTROGENS, METASTASIS.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE