Accession Number : ADA327144

Title :   The Development and Application of Cellular Sensitivity Biomarkers for the Detection and Measurement of Toxic Effects in Normal and Malignant Cells from Patients Receiving High-Dose Melphalan with Autologous Peripheral Blood Progenitor Cell Rescue in the Treatment of Metastic Breast Cancer.

Descriptive Note : Final rept. 1 sep 94-31 Aug 96,

Corporate Author : DUKE UNIV MEDICAL CENTER DURHAM NC

Personal Author(s) : Peters, William P. ; Hussein, Atif M. ; Vredenburgh, James J.

PDF Url : ADA327144

Report Date : FEB 1997

Pagination or Media Count : 36

Abstract : This study provides an extraordinary setting for applying biomarkers of cellular sensitivity to monitor and analyze therapeutic versus toxic effects in cancer chemotherapy. The difference between delivered and biologically effective doses of a drug is the consequence of many complex interacting factors. These include: absorption, cellular uptake, distribution, affinity for intended target tissue and excretion capacities; outcome of metabolic activation processes; ability to repair damage and levels of cofactors that modify drug action.

Descriptors :   *TOXICITY, *DOSAGE, *DRUGS, *BREAST CANCER, TISSUE CULTURE CELLS, DETECTION, INTERACTIONS, SENSITIVITY, METABOLISM, MARKERS, ABSORPTION, IN VIVO ANALYSIS, CELLS(BIOLOGY), CULTURES(BIOLOGY), CHEMOTHERAPY, TRACER STUDIES.

Subject Categories : Medicine and Medical Research
      Toxicology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE