Accession Number : ADA327148
Title : Regulation of Retinoid Responsiveness in Mammary Carcinoma Cells.
Descriptive Note : Annual rept. 1 Sep 95-31 Aug 96,
Corporate Author : COLUMBIA UNIV NEW YORK
Personal Author(s) : Talmage, David A.
PDF Url : ADA327148
Report Date : SEP 1996
Pagination or Media Count : 18
Abstract : The data presented in this annual report support our hypothesis for a mechanism of retinoid-induced growth arrest of human breast cancer cells. Specifically, we believe that retinoids inhibit human breast cancer cell proliferation by inducing a state of functional mitogen deprivation. Kinetic and quantitative changes in cell cycle progression and gene expression following retinoic acid treatment of the estrogen dependent, T-47D breast cancer cell line, are consistent with retinoic acid inducing a block in the treated cells' ability to respond to external mitogenic signals.
Descriptors : *CELLS(BIOLOGY), *GROWTH(PHYSIOLOGY), *VITAMIN A, *BREAST CANCER, HUMANS, PROTEINS, GENES, KINETICS, INHIBITORS, MAMMARY GLANDS, ESTROGENS.
Subject Categories : Biochemistry
Genetic Engineering and Molecular Biology
Anatomy and Physiology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE