Accession Number : ADA327374

Title :   The Development of an Effective Vaccine, Post Exposure Prophylaxis and for Prevention and Control of AIDS.

Descriptive Note : Annual rept. 1 May 96-30 Apr 97,

Corporate Author : UNITED BIOMEDICAL INC HAUPPAUGE NY

Personal Author(s) : Koff, Wayne C.

PDF Url : ADA327374

Report Date : MAY 1997

Pagination or Media Count : 46

Abstract : Studies undertaken in Year 2 of Grant DAMD 17-95-1-5031 focused on induction of complementary immune responses including neutralizing antibodies, mucosal immunity and cytotoxic T cells likely to be necessary for development of long-term protective immunity against IV infection and AIDS. Preclinical studies of DNA plasmid immunogens expressing MIV antigens and immunostimulatory cytokines for priming of cellular immune responses followed by subunit peptide immunogens for boosting humoral immunity provided a strategy for maximizing immune effector mechanisms. Similarly, preclinical studies utilizing systemic priming followed by mucosal boosting provided a strategy for addressing differential routes of HIV transmission. Finally, monoclonal antibodies previously identified with potent anti-HIV efficacy, demonstrated their ability to be effective in post-exposure prophylaxis studies, and synthetic immunogens are currently being evaluated to mimic to efficacy of these potent monoclonals.

Descriptors :   *EXPOSURE(PHYSIOLOGY), *INFECTIOUS DISEASES, *VACCINES, *ACQUIRED IMMUNE DEFICIENCY SYNDROME, *PREVENTIVE MEDICINE, CONTROL, PEPTIDES, NEUTRALIZATION, CLINICAL MEDICINE, LONG RANGE(TIME), DEOXYRIBONUCLEIC ACIDS, PLASMIDS, ANTIBODIES, ROUTING, CYTOTOXINS, RESPONSE(BIOLOGY), MONOCLONAL ANTIBODIES, T LYMPHOCYTES, IMMUNITY, CELLS(BIOLOGY), ANTIGENS, MUCOUS MEMBRANES, HUMORAL IMMUNITY, ADDRESSING.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE