Accession Number : ADA327719

Title :   Role of High-Affinity Oncostatin M Receptor in Prevention of Breast Cancer Cell Growth.

Descriptive Note : Annual rept. 1 Apr 96-31 Mar 97,

Corporate Author : VETERANS ADMINISTRATION MEDICAL CENTER BOISE ID

Personal Author(s) : Liu, Jingwen

PDF Url : ADA327719

Report Date : APR 1997

Pagination or Media Count : 28

Abstract : Recently, a novel breast cancer specific gene, designated BCSGl, was isolated from human breast cancer cDNA library by the differential cDNA sequencing approach. The mRNA of BCSGl is highly expressed in the infiltrating carcinomas but not expressed in the normal or benign breast tissues. We examined the expression of BCSGl expression in different breast cancer cell lines and investigated the effect of Oncostatin M (OM) on BCSGl gene expression in breast cancer cells. A kinetic study showed that treatment of H3922 cells with OM initiated an immediate decrease of BCSGl mRNA as early as 30 min. Our study suggests that down regulation of BCSGl expression may be involved in OM-mediated growth inhibition of breast cancer cells.

Descriptors :   *GENES, *CELLS(BIOLOGY), *GROWTH(PHYSIOLOGY), *BREAST CANCER, TISSUES(BIOLOGY), STIMULATION(PHYSIOLOGY), HUMANS, GLYCOPROTEINS, DEOXYRIBONUCLEIC ACIDS, KINETICS, PREVENTION, RIBONUCLEIC ACIDS, RECEPTOR SITES(PHYSIOLOGY), MACROPHAGES, CANCER, MAMMARY GLANDS.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE