Accession Number : ADA327999

Title :   Gas Uptake Kinetics of 1,1,1 ,3,3,3-Hexafluoropropane (HFC-236fa) and Identification of its Potential Metabolites.

Descriptive Note : Final rept. Apr-Jun 95,

Corporate Author : GEO-CENTERS INC NEWTON CENTRE MA

Personal Author(s) : Vinegar, Allen ; Buttler, Gerry W. ; Caracci, Melanie C. ; McCafferty, James D.

PDF Url : ADA327999

Report Date : NOV 1995

Pagination or Media Count : 48

Abstract : As part of the Navy's efforts to eliminate ozone depleting substances, a new refrigerant, HFC-236fa, has been developed through a joint EPA/Navy effort. This refrigerant is a replacement for refrigerant CFC-114 which is used in centrifugal chillers aboard surface ships and submarines. The aim of these studies was to measure tissue:air partition coefficients and to describe the kinetics of 1,1,1,3,3,3-hexafluoropropane (HFC-236fa) via recirculating gas uptake exposure methods and to look for and identify potential metabolites in blood and urine after inhalation exposure to HFC-236fa. A physiologically based pharmacokinetic (PBPK) model was used to describe mathematically the disposition and metabolism of HFC-236fa employing chemical-specific parameters and apparent whole-body metabolic constants calculated from these experiments. Samples from as uptake studies were collected from rats for the determination of potential metabolites of HFC-236fa in blood, urine and feces. Chamber air samples and moisture trap samples for differing exposure levels and durations were collected and analyzed. Possible metabolites that were considered were hexafluoroacetone, hexafluoropropanol and fluoro-carboxylic acids.

Descriptors :   *THERMAL PROPERTIES, *DEPLETION, *OZONE, *METABOLITES, *PROPANE, *FLUORENES, SHIPS, OCEAN SURFACE, EXPOSURE(GENERAL), RATS, AIR, METABOLISM, GASES, LEVEL(QUANTITY), KINETICS, MOISTURE, SUBMARINES, FECES, BLOOD, URINE, REFRIGERANTS, HEXANES.

Subject Categories : Inorganic Chemistry
      Polymer Chemistry
      Thermodynamics

Distribution Statement : APPROVED FOR PUBLIC RELEASE