Accession Number : ADA328004

Title :   Genetic Alterations in Familial Breast Cancer: Mapping and Cloning Genes Other than BRCA1.

Descriptive Note : Annual rept. 15 Aug 95-14 Aug 96,

Corporate Author : CALIFORNIA UNIV BERKELEY

Personal Author(s) : King, Mary-Claire ; Winkelstein Jr, Warren

PDF Url : ADA328004

Report Date : SEP 1996

Pagination or Media Count : 21

Abstract : The purpose of this project is to identify genes responsible for inherited susceptibility to breast cancer in families. Two such genes have been cloned (BRCA1 and BRCA2), but the existence of families with many cases of breast cancer but no mutations in these genes suggests that other BRCA genes may exist. Using an integrated approach involving dissection of germline chromosomal rearrangements in women with very early onset breast cancer, coupled with linkage analysis in families, we are cloning the gene on chromosome 10q responsible for Cowden disease and possibly for breast cancer in the absence of other Cowden symptoms.

Descriptors :   *GENETIC ENGINEERING, *BREAST CANCER, SIGNS AND SYMPTOMS, MUTATIONS, GENES, CLONES, LINKAGES, WOMEN, DISSECTION.

Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE