Accession Number : ADA328032

Title :   Transgenic Analysis of the Role of Transcription Factor AP-2 in Breast Development and Breast Cancer.

Descriptive Note : Annual rept. 1 Jul 96-30 Jun 97,

Corporate Author : YALE UNIV NEW HAVEN CT

Personal Author(s) : Zhang, Jian

PDF Url : ADA328032

Report Date : MAY 1997

Pagination or Media Count : 24

Abstract : One of the most alterations in human breast cancer is the overexpression of the c-erbB-2 protooncogene that has been shown to occur in 25-30% of human breast tumors. Recently this increased expression has been shown to correlate with the presence of the transcription factor AP-2. We have begun to determine the role of AP-2 both in normal mammary gland development and in breast cancer.

Descriptors :   *NEOPLASMS, *GENES, *MAMMARY GLANDS, *BREAST CANCER, BIOLOGY, HUMANS, ETIOLOGY, THERAPY, ANIMALS, MICE, BIOPSY.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE