Accession Number : ADA328033

Title :   Iodotrifluoromethane and Iodoheptafluoropropane Assessment of Cardiac Sensitisation Potential in Dogs.

Descriptive Note : Final rept. Nov 93-Feb 95,

Corporate Author : MANTECH ENVIRONMENTAL TECHNOLOGY INC DAYTON OH

Personal Author(s) : Kenny, T. J. ; Shepherd, C. K. ; Hardy, C. J.

PDF Url : ADA328033

Report Date : 21 FEB 1995

Pagination or Media Count : 40

Abstract : This study was designed to assess the cardiac sensitisation potential of CF3I and C3F7I in beagle dogs. Adrenaline was administered by intravenous injection before and during inhalation of test substances. The effect of the adrenaline of the ECG pattern was examined. Positive evidence of cardiac sensitisation would be observed as the presence of multifocal ventricular ectopic activity or ventricular fibrillation following adrenaline administration during inhalation of the test substance. CF3I was administered to dogs at concentration in air of 0.1, 0.2, 0.4, and l%v/v. At 0.1 and 0.2% there was no positive result. At each of 0.4 and 1.0% the first dog exposed responded positively with fatal ventricular fibrillation and consequently no other dogs were exposed at these levels. C3F%I was administered to 3 dogs at concentrations in air of 0.1, 0.2, and 0.4%v/v. At each of 0.1 and 0.4% one dog responded positively with multifocal ventricular ectopic bets. The dog responding positively at 1.0% was not subsequently exposed to any higher concentrations. At 0.2% there was no positive result. It is concluded that CF3I has cardiac sensitisation potential at concentrations of 0.4%v/v in air and that C3F71 has cardiac sensitisation potential at concentrations of 0. 1%v/v in air.

Descriptors :   *DOGS, *CARDIAC PATIENTS, *INJECTIONS(MEDICINE), *CARDIAC ARREST, TEST AND EVALUATION, CONCENTRATION(COMPOSITION), VEINS, INHALATION, ARRHYTHMIA, VENTRICLES, EPINEPHRINE.

Subject Categories : Biochemistry
      Biology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE