Accession Number : ADA328398

Title :   Effect of Levonorgestrel (NORPLANT) on the Immune Regulation of Bone Morphogenesis in Calvarial Cultures from the Laboratory Mouse (Mus muscularis).

Descriptive Note : Final rept. 1 Dec 94-30 Sep 95,

Corporate Author : DWIGHT DAVID EISENHOWER ARMY MEDICAL CENTER FORT GORDON GA

Personal Author(s) : Craft, David W. ; Raez, Arlynn G. ; Lapp, Carol A.

PDF Url : ADA328398

Report Date : OCT 1995

Pagination or Media Count : 19

Abstract : Steroid sex hormones such as estrogen and progesterone affect gingival and osseous tissues and can mediate cytokine production. When administered as oral contraceptives, these hormones affect bone morphogenesis and mediate periodontal disease. Norplant, the subdermal contraceptive implant, continually releases a synthetic progestin, levonorgestrel, for five years. In order to assess the impact of levonorgestrel on bone cells, murine calvarial cell cultures were harvested, grown to confluence and treated with levonorgestrel, progesterone and estrogen. The majority of the cells grown in these bone cell cultures were phenotypically and morphologically characteristic of an osteoblast.

Descriptors :   *IMMUNITY, *BONES, *MORPHOGENESIS, HORMONES, TISSUES(BIOLOGY), DISEASES, MICE, CELLS(BIOLOGY), CULTURES(BIOLOGY), ORAL INTAKE, DENTISTRY, SURGICAL IMPLANTATION, STEROIDS, PROGESTERONE, ESTROGENS, GINGIVAE, SEX HORMONES.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE