Accession Number : ADA328656

Title :   Amino Acid Sequence Transfer Operators and Metric Space Distortions of Proteins,

Corporate Author : INSTITUT DES HAUTES ETUDES SCIENTIFIQUES BURES-SUR-YVETTE (FRANCE)

Personal Author(s) : Mandell, Arnold J. ; Selz, Karen A.

PDF Url : ADA328656

Report Date : MAY 1993

Pagination or Media Count : 6

Abstract : Physical and chemical studies of protein dynamics often yield nonlinear distortions and multiplicities of time scales which are partially resolved via scaling solutions. Assuming that the internal basis of the metric relations of proteins is hydrophobic hydration. we demonstrate a relationship between an expanding group action on hydrophobic amino acid sequences and the fractional spatial scalings of amino acid monomeric mass distances in 25 representative proteins. This empirical relationship is analogous to that resulting from the tessellation of non-Euclidean spaces by discrete groups and suggests a route to physical uniformization of the data of protein dynamics without ad hoc scaling corrections.

Descriptors :   *ENZYMES, *PROTEINS, THERMODYNAMICS, X RAY DIFFRACTION, CRYSTALS, SEQUENCES, ALGEBRAIC TOPOLOGY, AMINO ACIDS, HYDROPHOBIC PROPERTIES, BIODYNAMICS.

Subject Categories : Biochemistry
      Crystallography
      Nuclear Physics & Elementary Particle Physics

Distribution Statement : APPROVED FOR PUBLIC RELEASE