Accession Number : ADA328822

Title :   Environmental Exposures, Genetic Polymorphisms and p53 Mutational Spectra in a Case-Control Study of Breast Cancer.

Descriptive Note : Annual rept. 1 Jan-31 Dec 95,

Corporate Author : NATIONAL CANCER INST BETHESDA MD

Personal Author(s) : Shields, Peter G.

PDF Url : ADA328822

Report Date : JAN 1996

Pagination or Media Count : 12

Abstract : The original goal of this project is to determine the frequency of genetic polymorphisms for carcinogen metabolism and the p53 mutational spectra in a previously conducted breast cancer study designed to assess nutritional risk factors, seeking to identify risk factors related to inheritable susceptibilities and chemical etiologies. We have determined that the NAT2 slow acetylator genotype and cigarette smoking is a risk factor for postmenopausal, but not premenopausal, women. Rapid acetylators are at risk if they consume processed meats. There was no association for CYP2E1 and breast cancer. Other genetic polymorphisms are either in progress or are completed (CYP2D6, MEH, ADH, APOE). Other parts of this study, including the p53 mutational spectra analysis and the ancillary studies corroborate these findings and develop smoking prevention strategies are currently in progress. Thus far, the findings of these studies are important because they are identifying new etiologies for breast cancer where behavior modification would lead to a decreased risk.

Descriptors :   *MUTATIONS, *GENETICS, *POLYMORPHISM, *BREAST CANCER, ENVIRONMENTS, METABOLISM, CASE STUDIES, MEAT, BEHAVIOR, EXPOSURE(PHYSIOLOGY), CARCINOGENS, WOMEN, TOBACCO SMOKING.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE