Accession Number : ADA328846

Title :   Myocardial Dysfunction Contributes to Irreversible Hemorrhagic Shock.

Descriptive Note : Interim rept. 1 Sep 96-15 Aug 97,

Corporate Author : LOUISIANA BOARD OF REGENTS BATON ROUGE

Personal Author(s) : McDonough, Kathleen H. ; Miller, Harvey I. ; Burns, Alastair H.

PDF Url : ADA328846

Report Date : 15 AUG 1997

Pagination or Media Count : 7

Abstract : We have performed a study of the effects of different time periods of hemorrhagic shock on isolated heart function of guinea pigs. In vivo hemodynamics were monitored during hemorrhage, shock and resuscitation and then intrinsic function of the heart was assessed. Three time periods were studied - 1, 2 or 3 hours of shock. In some animals shock lasted for 1 hour and then guinea pigs were resuscitated with whole blood or dextran 70,000 MW (same volume as the blood that was removed). The data collected from the isolated heart indicated that hemorrhagic shock lasting I, 2 or 3 hours by itself did not cause major dysfunction or the heart. The only change in heart function that seemed to occur was in the 3 hour shock group in which the left ventricular compliance was slightly depressed. In annals that had been resuscitated with whole blood or with 6% dextran, ventricular performance was depressed compared to control hearts and compared to hearts from animals in hemorrhagic shock suggesting that reperfusion contributed significantly to myocardial dysfunction resulting from hemorrhagic shock.

Descriptors :   *CARDIOVASCULAR SYSTEM, *HEMORRHAGIC SHOCK, DEXTRAN, ISOLATION, IN VIVO ANALYSIS, HEART, BLOOD, IRREVERSIBLE PROCESSES, DYSFUNCTION, MYOCARDIUM, RESUSCITATION, GUINEA PIGS, VENTRICLES.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE