Accession Number : ADA328968

Title :   Xenobiotic Modulation of Human Mammary Epithelial Cell Gap Junctional Intercellular Communication and Growth.

Descriptive Note : Annual rept. 20 May 96-19 May 97,

Corporate Author : MEDICAL COLL OF OHIO AT TOLEDO

Personal Author(s) : Ruch, Randall J.

PDF Url : ADA328968

Report Date : JUN 1997

Pagination or Media Count : 14

Abstract : The incidence of breast cancer is increasing dramatically in the United States. Man-made environmental agents such as pesticides, polychlorinated biphenyls (PCBs), phthalate esters, and dioxin have been implicated in this increase. Many xenobiotics such as DDT and PCBs have weak estrogenic activity and may enhance breast cancer formation by an estrogenic effect on breast epithelial cell growth. These agents can also inhibit gap junctional intercellular communication (GJIC); this reduction may also be involved in enhanced growth and breast cancer formation by these agents. The studies outlined in this proposal will determine whether there is a link between xenobiotic inhibition of human mammary epithelial cell GJIC, growth, and estrogenicity. These studies are highly relevant to the prevention of breast cancer. An understanding of the relationship between xenobiotic inhibition of GJIC, estrogenic activity, and the enhancement of growth in human breast epithelial cells will lead to more widely acceptable, mechanism-based arguments that xenobiotics are involved in the etiology of human breast cancer. This should lead to more focused regulatory efforts to reduce exposure to these agents.

Descriptors :   *EPITHELIUM, *MAMMARY GLANDS, *BREAST CANCER, UNITED STATES, OPTIMIZATION, ENVIRONMENTS, HUMANS, ETIOLOGY, MANMADE, EXPOSURE(PHYSIOLOGY), ESTERS, CELLS(BIOLOGY), PHTHALATES, PREVENTION, PESTICIDES, GROWTH(PHYSIOLOGY), POLYCHLORINATED BIPHENYLS, DIOXINS, DDT, ESTROGENS.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE