Accession Number : ADA329121

Title :   Yeast Genetics for Delineating Bax/Bc1 Pathway of Cell Death Regulation.

Descriptive Note : Annual rept. 1 Jul 96-30 Jun 97,

Corporate Author : BURNHAM INST LA JOLLA CA

Personal Author(s) : Reed, John C.

PDF Url : ADA329121

Report Date : JUL 1997

Pagination or Media Count : 30

Abstract : Two novel human genes were cloned that inhibit cell death and that therefore may contribute to breast cancer by preventing the normal cell turnover that is essential for keeping overall numbers of cells in the mammary gland within physiologically appropriate ranges. These genes suppress the pro-death activity of a protein called Bax. The Bax protein was shown previously to be present in normal mammary tissue but reduced or absent in one-third of breast cancers, in association with poor patient responses to chemotherapy and shorter overall survival. The cloning of these two new genes, termed Bl-1 and Bl-2 for Bax-inhibitors 1 and 2, may provide insights into how to restore the function of Bax in breast cancer which has reduced levels of this cell death promoting protein.

Descriptors :   *YEASTS, *GENETIC ENGINEERING, *BREAST CANCER, HUMANS, PROTEINS, GENES, CLONES, INHIBITORS, DEATH, CELLS(BIOLOGY), CHEMOTHERAPY, MAMMARY GLANDS.

Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE