Accession Number : ADA329299
Title : Interactions of HIV-1 and HIV-2 in West Africa.
Descriptive Note : Midterm rept. 15 Nov 94-14 Jun 97
Corporate Author : HARVARD COLL CAMBRIDGE MA
Personal Author(s) : Kanki, Phyllis
PDF Url : ADA329299
Report Date : JUL 1997
Pagination or Media Count : 29
Abstract : We have demonstrated in populations of HIV-2 and HIV-1 infected individuals that these related viruses have distinct biologic properties. We have shown over a 12 year period the differences in HIV-2 and HIV-1 incidence and prevalence; where HIV-2 appears to be less transmissible by heterosexual sex. In natural history studies we have shown significant differences in the progression to AIDS, where HIV-2 behaved as a less pathogenic virus. This led to the hypothesis that it might protect individuals from subsequent HIV-1 infection, which was shown in our recent studies. In preparation for future vaccine cohorts, we have characterized the HIV-1 subtypes in our seroconverting women and demonstrated differences in their progression to AIDS, with A subtypes showing a longer disease free incubation period compared to subtypes C,D, and G. Immunologic studies of these women have demonstrated that they are capable of recognizing subtype B targets, suggesting that vaccines based on subtype B could be broadly protective.
Descriptors : *MEDICAL SERVICES, *VIRUSES, *HUMAN IMMUNODEFICIENCY VIRUSES, *VACCINES, BIOLOGY, HYPOTHESES, IMMUNOLOGY, WOMEN, NATURAL HISTORY, WEST AFRICA.
Subject Categories : Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE