Accession Number : ADA329299

Title :   Interactions of HIV-1 and HIV-2 in West Africa.

Descriptive Note : Midterm rept. 15 Nov 94-14 Jun 97

Corporate Author : HARVARD COLL CAMBRIDGE MA

Personal Author(s) : Kanki, Phyllis

PDF Url : ADA329299

Report Date : JUL 1997

Pagination or Media Count : 29

Abstract : We have demonstrated in populations of HIV-2 and HIV-1 infected individuals that these related viruses have distinct biologic properties. We have shown over a 12 year period the differences in HIV-2 and HIV-1 incidence and prevalence; where HIV-2 appears to be less transmissible by heterosexual sex. In natural history studies we have shown significant differences in the progression to AIDS, where HIV-2 behaved as a less pathogenic virus. This led to the hypothesis that it might protect individuals from subsequent HIV-1 infection, which was shown in our recent studies. In preparation for future vaccine cohorts, we have characterized the HIV-1 subtypes in our seroconverting women and demonstrated differences in their progression to AIDS, with A subtypes showing a longer disease free incubation period compared to subtypes C,D, and G. Immunologic studies of these women have demonstrated that they are capable of recognizing subtype B targets, suggesting that vaccines based on subtype B could be broadly protective.

Descriptors :   *MEDICAL SERVICES, *VIRUSES, *HUMAN IMMUNODEFICIENCY VIRUSES, *VACCINES, BIOLOGY, HYPOTHESES, IMMUNOLOGY, WOMEN, NATURAL HISTORY, WEST AFRICA.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE