Accession Number : ADA329386

Title :   Acute and Subchronic Toxicity Evaluations of the Halon Replacement Candidate Phosphorus Tribromide

Descriptive Note : Final rept. Oct 96-May 97

Corporate Author : MAN TECH/GEO-CENTERS JOINT VENTURE TOXIC HAZARDS RESEARCH

Personal Author(s) : Wolfe, Robin E. ; Feldmann, Marcia L. ; Ellis, David H. ; Leahy, Harry F. ; Flemming, Carlyle D.

PDF Url : ADA329386

Report Date : SEP 1997

Pagination or Media Count : 40

Abstract : Phosphorus tribromide (PBr3) is being considered by the DOD as a possible replacement for Halon 1301. This study was designed to determine the effects following single, high-concentration exposures which could occur in accidents, as well as repeated, low-concentration exposures which could occur on flight lines or where maintenance commonly occurs. Application of 10 or 50 microliters neat PBr3 to intact skin of an anesthetized NZW rabbit caused edema and necrosis of the treated skin within 10 minutes of dosing. Microscopic examination confirmed necrosis of the skin and underlying areas, including the skeletal muscle of the subcutis.

Descriptors :   *TOXIC HAZARDS, *BROMIDES, *PHOSPHORUS COMPOUNDS, TEST AND EVALUATION, RATS, EXPOSURE(PHYSIOLOGY), OZONE, SKIN(ANATOMY), MEDICAL EXAMINATION, NECROSIS, RABBITS, EDEMA.

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE