Accession Number : ADA329508

Title :   Modeling of Arterial Baroceptor Feedback in a Hydromec Cardiovascular Pulse Duplicator System

Corporate Author : ARMSTRONG LAB BROOKS AFB TX AEROSPACE MEDICINE DIRECTORATE

Personal Author(s) : Convertino, Victor A.

PDF Url : ADA329508

Report Date : SEP 1997

Pagination or Media Count : 5

Abstract : We have developed a hydro-mechanical cardiovascular pulse duplicator system (CPDS) for modeling the systemic arterial system. The CPDS has the ability to reproduce physiologically equivalent aortic pressures and flows and has been used to test and evaluate electrical analog arterial models of the systemic circulation. Feedback from a flow probe from measuring flow through a simulated aorta has been developed for regulating cardiac output by controlling heart rate and/or stroke volume. The output from a pressure sensor adjacent to the flow probe provides the opportunity to regulate heart rate using pressure feedback. The primary objective of the proposed research was to test the hypothesis that a physiologically equivalent arterial-cardiac baroreflex feedback mechanism can be accurately modeled by integrating a pressure sensor into the existing CPDS. A secondary objective was to cross-validate the mechanical feedback model by comparing heart rate responses during tilt tests with those of existing physiologic experimental data. Because of significant cracks and leaks in various plexiglas parts of the original Ormec CPDS, a number of parts had to be refabricated. All of the parts subjected to the most stress were refabricated from aluminum and anodized for protection against corrosion. Aluminized parts included both walls of the atrium and inlet hose connection, and all inlet and outlet hose connections to the Systemic Reservoir with their supporting parts. All other parts which included the walls surrounding the mitral valve test section required fabrication from plexiglas in order to provide a clear view of the valve in the test section. All hardware fabrication has been and have been completed completed by the fabrication shop at Brooks AFB.

Descriptors :   *BIOMECHANICS, *AORTA, PHYSIOLOGICAL EFFECTS, RESPONSE(BIOLOGY), HEART RATE, BLOOD CIRCULATION, ARTERIES, BLOOD PRESSURE.

Subject Categories : Bionics

Distribution Statement : APPROVED FOR PUBLIC RELEASE