Accession Number : ADA329702

Title :   Cerebellar Circuit Mechanisms Which Accompany Coordinated Limb Trajectory Patterns in the Rat: Use of a Model of Spontaneous Changes

Descriptive Note : Final rept. 15 Feb 93-14 Feb 97

Corporate Author : HAHNEMANN MEDICAL COLL AND HOSPITAL PHILADELPHIA PA DEPT OF ANATOMY

Personal Author(s) : Smith, Sherry

PDF Url : ADA329702

Report Date : FEB 1997

Pagination or Media Count : 4

Abstract : This project was designed to evaluate the effect of estrous hormones on function of the olivo-cerebellar circuitry in association with improved motor performance. Towards this end rats were chronically implanted with arrays of microwires to record from the dorsal accessory olive (rDAO) and its target, Purkinje cells in the paravermal cerebellum. In many cases, simultaneous recordings were carried out from as many as 48 neurons in both areas during tredmill locomotion tasks used to evaluate concomitant sensorimotor performance. The justification for these studies comes from the findings that elevations in endogenous estrous hormones across the estrous cycle are associated with marked improvements in limb trajectory. Our fundings suggest that the ability of a rat to maintain treadmill position on a variable speed treadmill paradigm is improved on the night of behavioral estrus, following elevations in both estrous hormones, estradiol and progesterone.

Descriptors :   *HORMONES, *MOTOR REACTIONS, *CEREBELLUM, MODELS, RATS, PATTERNS, TRAJECTORIES, EXTREMITIES, TREADMILLS, PROGESTERONE, ESTROUS CYCLE, ESTROGENS, LOCOMOTION.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE