Accession Number : ADA330147
Title : Developing Novel Conjugate HIV-1 Subunit Therapeutic Vaccines
Descriptive Note : Annual rept. 1 Jun 96-31 May 97
Corporate Author : SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH SAN ANTONIO TX
Personal Author(s) : Giavedoni, Luis D.
PDF Url : ADA330147
Report Date : JUN 1997
Pagination or Media Count : 14
Abstract : Highly pure, native preparations of recombinant gp120 have been obtained from the T-tropic HIV-l(LAI) and the macrophage-tropic HIV-l(JR-FL) isolates. Conjugates of these HIV-l gp120 preparations were prepared with tetanus toxoid (TT) and keyhole limpet hemocyanin (KHL) with the hypothesis that very immunogenic carrier proteins will increase the immunogenicity of gp 120.
Descriptors : *HUMAN IMMUNODEFICIENCY VIRUSES, *VACCINES, PROTEINS, DEOXYRIBONUCLEIC ACIDS, CODING, ANTIBODIES, GENES, CELLS(BIOLOGY), IMMUNIZATION, MACROPHAGES, IMMUNOGENS, CLOSTRIDIUM TETANI.
Subject Categories : Biochemistry
Genetic Engineering and Molecular Biology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE