Accession Number : ADA330147

Title :   Developing Novel Conjugate HIV-1 Subunit Therapeutic Vaccines

Descriptive Note : Annual rept. 1 Jun 96-31 May 97

Corporate Author : SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH SAN ANTONIO TX

Personal Author(s) : Giavedoni, Luis D.

PDF Url : ADA330147

Report Date : JUN 1997

Pagination or Media Count : 14

Abstract : Highly pure, native preparations of recombinant gp120 have been obtained from the T-tropic HIV-l(LAI) and the macrophage-tropic HIV-l(JR-FL) isolates. Conjugates of these HIV-l gp120 preparations were prepared with tetanus toxoid (TT) and keyhole limpet hemocyanin (KHL) with the hypothesis that very immunogenic carrier proteins will increase the immunogenicity of gp 120.

Descriptors :   *HUMAN IMMUNODEFICIENCY VIRUSES, *VACCINES, PROTEINS, DEOXYRIBONUCLEIC ACIDS, CODING, ANTIBODIES, GENES, CELLS(BIOLOGY), IMMUNIZATION, MACROPHAGES, IMMUNOGENS, CLOSTRIDIUM TETANI.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE