Accession Number : ADA330711

Title :   A Genetic Approach to Mammalian Circadian Rhythms.

Descriptive Note : Final rept. 1 May 94-30 Apr 97

Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA SCHOOL OF MEDICINE

Personal Author(s) : Bucan, Maja

PDF Url : ADA330711

Report Date : 1995

Pagination or Media Count : 6

Abstract : We have developed a routine procedure for random mutagenesis in the mouse and have demonstrated the feasibility of rapidly screening for aberrant behavioral parameters. We believe that this classical genetic approach, as well as the screening of progeny of mutagenized mice for altered sequence and/or expression pattern prior to phenotypic analysis, will play an important role in the elucidation of the functional content of the mammalian genome.

Descriptors :   *CIRCADIAN RHYTHMS, *MAMMALS, *GENETICS, PARAMETERS, MUTATIONS, CHROMOSOMES, SEQUENCES, TOXIC AGENTS, PATTERNS, BEHAVIOR, MICE, ABNORMALITIES.

Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE