Accession Number : ADA331171

Title :   Human Breast Cancer Cell Proliferation and Modulation by Melatonin and Environmental Magnetic Fields

Descriptive Note : Final rept. 1 Jul 94-30 Apr 97

Corporate Author : CALIFORNIA UNIV BERKELEY LAWRENCE BERKELEY LAB

Personal Author(s) : Liburdy, Robert P.

PDF Url : ADA331171

Report Date : MAY 1997

Pagination or Media Count : 73

Abstract : The overall purpose of this study is to investigate the role that environmental-level magnetic fields may play as an exogenous factor in the etiology of human breast cancer. During this two-year research period significant progress has been made. We have observed that (a) the hormone melatonin and drug tamoxifen, which both inhibit human breast cancer cell growth, are each blocked or inhibited by environmental-level 12 mG (60Hz) magnetic fields; (b) this effect is observed at physiological levels of melatonin and pharmacological levels of tamoxifen; (c) an exposure dose-response exists between 2-12 mG for melatonin; (d) exposure duration data indicates field treatment is required for at least one cell cycle; (e) the magnetic field not the electric field is the operative field metric; and (f) frequency dependency experiments suggest this interaction is consistent with relatively long times of milliseconds implicating slow biological based processes.

Descriptors :   *MAGNETIC FIELDS, *HUMANS, *MELATONIN, *BREAST CANCER, HORMONES, ENVIRONMENTS, RISK, IN VITRO ANALYSIS, ETIOLOGY, PHYSIOLOGY, EXPOSURE(PHYSIOLOGY), RESPONSE(BIOLOGY), CELLS(BIOLOGY), PHARMACOLOGY, GROWTH(PHYSIOLOGY).

Subject Categories : Biochemistry
      Medicine and Medical Research
      Pharmacology
      Electricity and Magnetism

Distribution Statement : APPROVED FOR PUBLIC RELEASE