Accession Number : ADA331555

Title :   Role of Accessory Molecule(s) in Endotoxin-Endothelial Interactions and Endothelial Barrier Dysfunction.

Descriptive Note : Annual rept. 1 Jun 96-31 May 97,

Corporate Author : MARYLAND UNIV BALTIMORE SCHOOL OF MEDICINE

Personal Author(s) : Goldblum, Simeon E.

PDF Url : ADA331555

Report Date : JUL 1997

Pagination or Media Count : 18

Abstract : We have studied the direct impact of endotoxin or bacterial lipopolysaccharide (LPS) on pulmonary vascular endothelial cell (EC) barrier function. We have found that LPS induces (1) tyrosine phosphorylation of a 65kDa protein, paxillin, (2) actin disassembly, and (3) opening of the paracellular pathway. The tyrosine phosphorylation events were clearly prerequisite to the downstream events of actin depolymerization, opening of the paracellular pathway, and loss of endothelial barrier function.

Descriptors :   *BACTERIA, *ENDOTOXINS, *ENDOTHELIUM, *LIPOPOLYSACCHARIDES, FUNCTIONS, IMPACT, INTERACTIONS, MOLECULES, BARRIERS, LUNG, CELLS(BIOLOGY), DEPOLYMERIZATION, CARDIOVASCULAR SYSTEM, DYSFUNCTION, TYROSINE, DISASSEMBLY, PHOSPHORYLATION, MUSCLE PROTEINS.

Subject Categories : Biochemistry
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE