Accession Number : ADA331912

Title :   Autonomic Functions Associated with Blood Pressure Regulation and Orthostatic Performance in Women.

Descriptive Note : Final rept. 22 Dec 95-31 Aug 97,

Corporate Author : ARMSTRONG LAB BROOKS AFB TX AEROSPACE MEDICINE DIRECTORATE

Personal Author(s) : Convertino, Victor A.

PDF Url : ADA331912

Report Date : OCT 1997

Pagination or Media Count : 37

Abstract : Functions of baroreflex control of heart rate and vascular resistance, adrenoreceptor responsiveness, indices of baseline vagal and sympathetic tone, plasma volume, and venous compliance were compared in men and women to test the hypothesis that greater orthostatic intolerance in women would be associated with impairment of specific mechanisms of blood pressure regulation. Heart rate (HR), stroke volume (SV), cardiac output (Q), mean arterial blood pressure (MAP), forearm (FVR) and leg (LVR) vascular resistance, catecholamines (NE), and changes in leg volume (%LV) were measured during various protocols of lower body negative pressure (LBNP), carotid stimulation, and infusions of adrenoreceptor agonists in 10 females and 10 males matched for age and fitness. LBNP tolerance for women (797 +/- 63 mmHg.min) was 35% lower (P 0.0017) than for men. At presyncope, SV, Q, MAP and %LV were tolerance in females was associated with impairment of the heart rate response to carotid baroreceptor stimulation, lower baseline cardiac vagal activity, greater decline in Q and SV induced by LBNP, increased B1-adrenoreceptor responsiveness, greater vasoconstriction under equal LBNP, lower levels of NE at presyncope, and lower blood volume. Results support the hypothesis that women have significant deficiencies in mechanisms that underlie blood pressure regulation under orthostatic challenge. These findings should be considered in selection and training of women for military combat, especially in combat missions requiring high-G aerial maneuvers.

Descriptors :   *WOMEN, *AUTONOMIC NERVOUS SYSTEM, *BLOOD PRESSURE, *ORTHOSTATISM, STIMULATION(GENERAL), TRAINING, BASE LINES, MILITARY MEDICINE, HUMAN BODY, STATISTICAL ANALYSIS, HYPOTHESES, PATHOLOGY, THORAX, RESPONSE(BIOLOGY), MEDICAL RESEARCH, CATECHOLAMINES, HEART RATE, CARDIOVASCULAR SYSTEM, HEART, SENSE ORGANS, BLOOD VOLUME, RESISTANCE(BIOLOGY), REFLEXES, CAROTID ARTERIES, PULMONARY FUNCTION, VASOCONSTRICTING, PRESSURE REGULATORS, HEART FUNCTION TESTS, LUNG FUNCTION TESTS.

Subject Categories : Biology
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE