Accession Number : ADA332239

Title :   ONR Augmentation Award Final Technical Report

Corporate Author : OFFICE OF NAVAL RESEARCH ARLINGTON VA

Personal Author(s) : Ellington, Andy

PDF Url : ADA332239

Report Date : 1997

Pagination or Media Count : 2

Abstract : The ONR Augmentation Award was used to support Scott Baskerville, a graduate student in my lab. Scott's research was directed towards increasing our understanding of how selected RNA molecules can recognize target ligands. As a model system, Scott studied how arginine-rich motifs (ARMs) frequently found in viral proteins can recognize RNA molecules. This model system was chosen because we had previously observed that RNA molecules that bind to ARMs frequently contained a discrete arginine-binding site (Ellington et al., 1995; Ellington et al., 1996). We had hypothesized that residues adjacent to the arginine-binding site were important in determining the specificity of ARM:RNA interactions. In other words, we believed that we had identified a potential 'code' for at least one class of peptide:RNA interactions. By deciphering this code, we hoped to better understand whether and how molecular sequence could be directly mapped to molecular recognition.

Descriptors :   *VIRUSES, *RIBONUCLEIC ACIDS, MODELS, STUDENTS, INTERACTIONS, MOLECULES, PEPTIDES, PROTEINS, TARGETS, SEQUENCES, LIGANDS, RECOGNITION.

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE