Accession Number : ADA332260
Title : Autonomic Functions Associated with Blood Pressure Regulation and Orthostatic Performance in Women.
Descriptive Note : Final rept.
Corporate Author : ARMSTRONG LAB BROOKS AFB TX
Personal Author(s) : Convertino, Victor A.
PDF Url : ADA332260
Report Date : AUG 1997
Pagination or Media Count : 54
Abstract : Functions of baroreflex control of heart rate and vascular resistance, adrenoreceptor responsiveness, indices of baseline vagal and sympathetic tone, plasma volume, and venous compliance were compared in men and women to test the hypothesis that greater orthostatic intolerance in women would be associated with impairment of specific mechanisms of blood pressure regulation. Heart rate (HR), stroke volume (SV), cardiac output (Q), mean arterial blood pressure (MAP), forearm (FVR) and leg (LVR) vascular resistance, catecholamines (NE), and changes in leg volume (%LV) were measured during various protocols of lower body negative pressure (LBNP), carotid stimulation, and infusions of adrenoreceptor agonists in 10 females and 10 males matched for age and fitness. LBNP tolerance for women (797 +/- 63 mmHg.min) was 35% lower (P=0.0017) than for men. At presyncope, SV, Q, MAP and %LV were lower (P<0.05) in females compared to males while HR, FVR, and TPR were similar in both groups. Lower LBNP tolerance in females was associated with impairment of the heart rate response to carotid baroreceptor stimulation, lower baseline cardiac vagal activity, greater decline in Q and SV induced by LBNP, increased Beta1-adrenoreceptor responsiveness, greater vasoconstriction under equal LBNP, lower levels of NE at presyncope, and lower blood volume. Results support the hypothesis that women have significant deficiencies in mechanisms that underlie blood pressure regulation under orthostatic challenge. These findings should be considered in selection and training of women for military combat, especially in combat missions requiring high-G aerial maneuvers.
Descriptors : *WOMEN, *BLOOD PRESSURE, *ORTHOSTATISM, MILITARY PERSONNEL, CARDIOVASCULAR SYSTEM, BLOOD VOLUME, VASOCONSTRICTING.
Subject Categories : Anatomy and Physiology
Distribution Statement : APPROVED FOR PUBLIC RELEASE