Accession Number : ADA332321

Title :   Xenograft Studies of Fatty Acid Synthesis Inhibition as Novel Therapy for Breast Cancer

Descriptive Note : ANNUAL REPT 1 Aug 96-31 JUl 97

Corporate Author : JOHNS HOPKINS UNIV BALTIMORE MD

Personal Author(s) : Pasternack, Gay R.

PDF Url : ADA332321

Report Date : AUG 1997

Pagination or Media Count : 11

Abstract : Fatty acid synthesis inhibitors were studied as a means to treat breast cancer in vivo. A nude mouse model of MDA-435 was validated and the fatty acid synthesis inhibitor, C-75, was shown to substantially inhibit the growth of MDA- 435 in a local intraperitoneal treatment model. Studies were carried out addressing the mechanism of C-75 which, while not yet conclusive, have shown a degree of fatty acid synthase inhibition. Additional candidate compounds for in vivo analysis have been identified.

Descriptors :   *SYNTHESIS, *FATTY ACIDS, *BREAST CANCER, IMMUNOLOGY, INHIBITORS, SYNTHASES, IN VIVO ANALYSIS.

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE