Accession Number : ADA332329

Title :   Evaluating Gene Therapy Approaches for the Prevention of Breast Cancer

Descriptive Note : Annual rept 1 Jul 96-30 Jun 97

Corporate Author : WISCONSIN UNIV-MADISON

Personal Author(s) : Gould, Michael N. ; Watson, Philip

PDF Url : ADA332329

Report Date : JUL 1997

Pagination or Media Count : 40

Abstract : In order to determine the feasibility of using gene therapy for breast cancer prevention in the rat, lacZ recombinant adenoviral and retroviral vectors were infused into the mammary glands of rats in situ. Staining of whole glands with X-gal revealed the location of infected cells. Adenovirus infected the end buds with high efficiency but failed to infect the primary/secondary ductal cells. Expression of lacZ from the adenoviral vector was transient, with no expression by day 8 post-infusion.

Descriptors :   *GENES, *PREVENTION, *BREAST CANCER, HIGH RATE, RATS, EFFICIENCY, ADENOVIRUSES, MAMMARY GLANDS, DISEASE VECTORS, GLANDS, RETROVIRUSES.

Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE