Accession Number : ADA332341

Title :   Role of Bone Sialoproteins in Osseous Metastasis of Breast Cancer

Descriptive Note : Annual rept 1 Jul 96-30 Jun 97

Corporate Author : GEORGETOWN UNIV WASHINGTON DC

Personal Author(s) : Sung, Victoria

PDF Url : ADA332341

Report Date : JUL 1997

Pagination or Media Count : 64

Abstract : The ability of certain human breast cancer cells (HBC) to metastasize to bone may be related to cellular expression of the small acidic sialoproteins osteopontin (OPN) and bone sialoprotein (BSP). Expression of these proteins may promote primary tumor cell invasion, and/or the development of bone metastases. The purpose of this study is to compare BSP and OPN expression in HBC to bone metastatic potential and to examine potential breast cancer cell responses to BSP.

Descriptors :   *PROTEINS, *BONES, *METASTASIS, *BREAST CANCER, HUMANS, PEPTIDES, NEOPLASMS, ANTIBODIES, CELLS(BIOLOGY), OSTEOLYSIS.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE