Accession Number : ADA332341
Title : Role of Bone Sialoproteins in Osseous Metastasis of Breast Cancer
Descriptive Note : Annual rept 1 Jul 96-30 Jun 97
Corporate Author : GEORGETOWN UNIV WASHINGTON DC
Personal Author(s) : Sung, Victoria
PDF Url : ADA332341
Report Date : JUL 1997
Pagination or Media Count : 64
Abstract : The ability of certain human breast cancer cells (HBC) to metastasize to bone may be related to cellular expression of the small acidic sialoproteins osteopontin (OPN) and bone sialoprotein (BSP). Expression of these proteins may promote primary tumor cell invasion, and/or the development of bone metastases. The purpose of this study is to compare BSP and OPN expression in HBC to bone metastatic potential and to examine potential breast cancer cell responses to BSP.
Descriptors : *PROTEINS, *BONES, *METASTASIS, *BREAST CANCER, HUMANS, PEPTIDES, NEOPLASMS, ANTIBODIES, CELLS(BIOLOGY), OSTEOLYSIS.
Subject Categories : Biochemistry
Anatomy and Physiology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE