Accession Number : ADA332441

Title :   Role of HMG-I(Y) in Human Breast Cancer Metastasis.

Descriptive Note : Annual rept.,

Corporate Author : WASHINGTON STATE UNIV PULLMAN

Personal Author(s) : Li, Ying

PDF Url : ADA332441

Report Date : JUL 1997

Pagination or Media Count : 17

Abstract : HMG-I(Y) proteins are mammalian architectural transcription factors. They have been demonstrated to be necessary for the transcriptional regulation of a number of genes, including the genes associated with tumorigenesis and metastasis. It was proposed in the original grant that over-expression of HMG-I(Y) proteins in breast cancer cells will fundamentally influence the expression, of genes that are involved in metastatic invasion, migration, angiogenesis and colonization. In the first year of study, the preliminary results support the hypothesis. They include (1) over-expression of HMG-I(Y) in the human breast cancer cell line MCF-7 leads to higher tumorgenic potential, (2) HMG-I(Y) proteins can physically interact with promoter regions of the matrix metalloprotease MMP-3. In addition, new findings have been obtained that HMG-I(Y) proteins can be phosphorylated by protein kinase C in vitro and phosphorylation of HMO-I(Y) proteins can be induced by the mitogen PMA in the human breast cancer cell line Hs578T in vivo. These results indicated that HMO-I(Y) proteins indeed may play an important role in tumor metastasis.

Descriptors :   *MAMMARY GLANDS, *BREAST CANCER, CORRELATION, GENES, RECEPTOR SITES(PHYSIOLOGY), METASTASIS.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE