Accession Number : ADA332454

Title :   Microvasculature Magnetic Resonance Imaging for the Diagnosis of Breast Cancer

Descriptive Note : Annual rept 1 May 96-30-Apr 97

Corporate Author : JOHN P ROBARTS RESEARCH INST LONDON (ONTARIO)

Personal Author(s) : Maier, Cynthiaa F. ; Rutt, Brian K.

PDF Url : ADA332454

Report Date : JUN 1997

Pagination or Media Count : 70

Abstract : The work comprising this thesis is directed toward developing new techniques for measuring tumor blood flow in human breast lesions using MRI. The first section of this thesis addresses the underlying biological question of whether malignant breast lesions can be distinguished from benign lesions on the basis of microvessel density and flow. A second major focus of this thesis describes the design and construction of a prototype breast gradient coil set to be used as a hardware add-on with the regular clinical MR scanner. The third section of this thesis involves the application of a new MRI method for measuring blood flow in the microvasculature, Intravoxel Incoherent Motion imaging (IVIM) to an animal model of tumor blood flow.

Descriptors :   *BREAST CANCER, *MAGNETIC RESONANCE IMAGING, HUMANS, NEOPLASMS, DIAGNOSIS(MEDICINE), IMAGES, BLOOD CIRCULATION, VASCULAR DISEASES, MAMMARY GLANDS.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Optics

Distribution Statement : APPROVED FOR PUBLIC RELEASE