Accession Number : ADA332505

Title :   Substrate Induced Conformational Studies of the Hormone Binding Domain of the Human Estrogen Receptor by Fluorine NMR

Descriptive Note : Annual reept 1 Jul 96-30 Jun 97

Corporate Author : CLARKSON UNIV POTSDAM NY

Personal Author(s) : Luck, Linda

PDF Url : ADA332505

Report Date : JUL 1997

Pagination or Media Count : 14

Abstract : Estrogen has been shown to be involved in the progression of breast cancer and the estrogen receptor (ER) has been implicated in reproductive cancers. Our laboratory would like to understand how the structure of the hormone binding domain (HBD) of the ER changes when it is "activated" by estrogens and anti- estrogens. Since the binding of estradiol to its receptor ultimately leads to diverse biological responses to the hormone, we would like to investigate the response of the receptor to a series of ligands and illucidate the molecular basis for their functional differences.

Descriptors :   *HORMONES, *FLUORINE, *ESTROGENS, *BREAST CANCER, HUMANS, RESPONSE, LIGANDS, RESPONSE(BIOLOGY), RECEPTOR SITES(PHYSIOLOGY).

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE