Accession Number : ADA332636

Title :   Transgenic Repository for Breast Cancer Research.

Descriptive Note : Annual rept. 1 Jun 96-31 May 97,

Corporate Author : JACKSON LAB BAR HARBOR ME

Personal Author(s) : Davisson, Mauriel T.

PDF Url : ADA332636

Report Date : JUL 1997

Pagination or Media Count : 20

Abstract : The overall goal of this project is to develop and maintain a resource of mouse models for breast cancer research. In the 03 year 12 induced mutant strains have been identified and accepted for importation into The Jackson Laboratory (TJL) Induced Mutant Resource (IMR) repository for breast cancer research models. The importation process frees mice of infectious pathogens. Embryos or gametes are cryopreserved. Correct nomenclature is assigned, efficient breeding strategies are developed, and genotyping protocols are modified for optimal efficiency and accuracy. Strain availability is announced in several media, including a page on the IMR's World Wide Web site, accessed through TJL's WWW home page. A principal aim of this project is to transfer relevant mutations to a defined genetic background. Nine mutations are being transferred, including 7 to the FVB/NJ inbred background. Reports by others and our own observations suggest that tumor characteristics may be altered as a consequence of background strain modifiers. Congenic strains require characterization of tumor onset and type.

Descriptors :   *MUTATIONS, *GENETICS, *BREAST CANCER, GLOBAL, MICE, INFECTIOUS DISEASES, MEDICAL RESEARCH, EMBRYOS, PATHOGENIC MICROORGANISMS, BREEDING.

Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE